Paolo Maiuri

This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.

The paper shows that chromatin condensates, regulated by MLL4, modulate nuclear mechano-sensing and prevent cGAS-STING activation in Kabuki Syndrome.

This study establishes an in vitro model of SORD deficiency using iPSCs and identifies mitochondrial dysfunction and oxidative stress as key mechanisms, suggesting AR inhibition as a therapeutic target for CMT2/SORD and diabetic neuropathies.

This study shows that LIN28A mediates RNA-dependent interactions with PRC2 to regulate chromatin dynamics and neuronal differentiation in ESCs.

This study shows that substrate stiffness affects fibroblast phenotype, contractility, and migration independently of TGF-β stimulation during wound healing.