Alessio Zippo

A generative network model reveals hierarchical structural memory guiding post-mitotic 3D genome inheritance

The paper introduces HiCONA, a Bayesian framework that identifies mitotically preserved chromatin interactions guiding post-mitotic 3D genome reassembly and epigenetic memory.

Chromatin condensates tune nuclear mechano-sensing in Kabuki Syndrome by constraining cGAS activation

The paper shows that chromatin condensates, regulated by MLL4, modulate nuclear mechano-sensing and prevent cGAS-STING activation in Kabuki Syndrome.

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer

The paper identifies ANP32E as a driver of vulnerability to ATR inhibitors in triple-negative breast cancer by promoting R-loop-dependent transcription replication conflicts and genomic instability.

Metastatic cell plasticity is maintained by SOX9 function during mitosis in breast cancer

The paper shows that SOX9 maintains metastatic cell plasticity during mitosis by priming chromatin accessibility for dormancy-related transcriptional programs in breast cancer.