Mitochondrial ROS-induced metabolic alterations differentially regulate ferroptosis sensitivity
Somesh Banerjee, Matthew Ryan Smith, Yining Irene Wang, Michael Wang, Derrik Gratz, Gregory K. Tharp, Sumin Kang, Peijian He
The paper identifies mtROS-induced metabolic changes that regulate ferroptosis sensitivity by affecting glutathione and CoQ biosynthesis in hepatocytes and cancer cells.
bioRxiv · Dec 23, 2025 · PreprintCell Biology