Matthew Ryan Smith

Development of a metabolomics-based index to monitor dietary effects on chronic inflammation: The Dietary Metabolomics Inflammation Index

The paper develops and tests the Dietary Metabolite Inflammatory Index (DMII) to assess diet-related chronic inflammation using metabolomics data, showing correlations with inflammation biomarkers.

Mitochondrial ROS-induced metabolic alterations differentially regulate ferroptosis sensitivity

The paper identifies mtROS-induced metabolic changes that regulate ferroptosis sensitivity by affecting glutathione and CoQ biosynthesis in hepatocytes and cancer cells.

Metabolic Trajectories During Surgical Stress in Patients Undergoing Cardiac Surgery

This study identifies metabolic pathways associated with stress hyperglycemia during cardiac surgery using longitudinal metabolomics and machine learning.

Multi-Tissue Metabolomics Reveal mtDNA- and Diet-Specific Metabolite Profiles in a Mouse Model of Cardiometabolic Disease

This study identifies mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease, revealing nDNA-mtDNA interactions that influence metabolic pathways and insulin resistance.

Metabolic effects of the schizophrenia-associated 3q29 deletion are sex-specific and uncoupled from behavioral phenotypes

This study shows that the 3q29 deletion causes sex-specific metabolic changes in mice, which are not linked to behavioral issues, and that a high-fat diet can improve weight in females without worsening behavior.

Use of an integrated pan-cancer oncology enrichment NGS assay to measure tumour mutational burden and detect clinically actionable variants

The paper evaluates the TruSight Oncology 500 assay for measuring tumour mutational burden and detecting clinically actionable variants, showing strong correlation with whole genome sequencing and orthogonal methods.