BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level
Uttam Anand, Shubhadeep Patra, Rohith Vedhthaanth Sekar…·Michael T. Woodside
The paper compares single-molecule folding dynamics of PrP from three mammalian species with different disease susceptibility, revealing sequence-driven differences in folding pathways and misfolding propensity.