Peptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epithelium
Jinzhen Hu, Michael B. Papah, Arlett Ramirez, Deepthi Alapati, Millicent O. Sullivan
This study develops peptide-lipid nanoparticles (hpLNPs) for pulmonary DNA delivery, showing enhanced transgene expression and demonstrating the importance of serum interactions for in vivo efficacy.
bioRxiv · Jul 13, 2026 · PreprintBioengineering