Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia
August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B. Miller, Brian H. Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J. Travaglini, , Christopher A. Walsh
The paper identifies somatic driver mutations in microglia of Alzheimer's disease brains, showing increased clonal expansion and inflammatory signatures.
bioRxiv · Jan 3, 2024 · PreprintGenomics