Jeong Ho Lee

This study identifies glial progenitor cells as the cell-of-origin for IDH-mutant gliomas by analyzing patient tissues and mouse models.

This study shows that a low number of mTOR mutant neurons can cause seizures in mice, and similar low levels of mosaicism are found in human patients.

The paper analyzes low-level somatic mutations across multiple organs and developmental stages, finding stage- and tissue-specific mutational features.

The paper identifies noncoding de novo mutations contributing to autism spectrum disorder by altering chromatin interactions and gene expression in neural stem cells.

RePlow improves low-VAF somatic mutation detection by using technical replicates, reducing false positives by up to 99%.