Author

Edward Stronge

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1

Frequent Co-Authors

August Yue HuangiD· 2 shared Brian H. ChhoukiD· 2 shared Christopher A. WalshiD· 2 shared Maya TalukdariD· 2 shared Sattar KhoshkhooiD· 2 shared Zinan ZhouiD· 2 shared Alissa M. D’GamaiD· 1 shared Annapurna PoduriiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

August Yue HuangORCID

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2 papers

Recent·Most cited

Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs

Sara Bizzotto, Maya Talukdar, Edward Stronge, Rosita B. Ramirez, Yingxi Yang, August Yue Huang, Qiwen Hu, Yingping Hou, Norma K. Hylton, Benjamin Finander, Ashton Tillett, Zinan Zhou, Brian H. Chhouk, Alissa M. D’Gama, Edward Yang, , Christopher A. Walsh

This study uses snRNA-seq and a new method called GO-TEN to analyze mosaic genetic variants in focal cortical dysplasia, revealing cell-autonomous and non-cell-autonomous transcriptional changes associated with epilepsy.

Proceedings of the National Academy of Sciences · Jul 17, 2025Peer-reviewedGenetics

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia

August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B. Miller, Brian H. Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J. Travaglini, , Christopher A. Walsh

The paper identifies somatic driver mutations in microglia of Alzheimer's disease brains, showing increased clonal expansion and inflammatory signatures.

bioRxiv · Jan 3, 2024 · PreprintGenomics