Live-cell single-molecule fluorescence microscopy for protruding organelles reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of inner ear hair cells
Takushi Miyoshi, Harshad D. Vishwasrao, Inna A. Belyantseva, Junko Miyoshi, Mrudhula Sajeevadathan, Yasuko Ishibashi, Samuel Mawuli Adadey, Narinobu Harada, Hari Shroff, Thomas B. Friedman
This study uses live-cell single-molecule fluorescence microscopy to investigate MYO7A trafficking in stereocilia, revealing its dimeric form and movement restrictions mediated by plasma membrane and F-actin interactions.
Nature Communications · Sep 1, 2025Peer-reviewedCell Biology