Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteome
Amber Emmett, Xiaoguang Xu, Xiao Jiang, Shadi Hames-Fathi, David Scannali, James Eales, Ewa Miller‐Kasprzak, Polly J. Downton, Antony D. Adamson, Yong Sun, Abigail C. Lay, David Talavera, Matthew J. Denniff, John Dormer, Grzegorz Rempega, , Maciej Tomaszewski
The paper identifies 508 CKD-associated genetic loci, prioritizes 651 kidney genes, and highlights novel CKD genes like CA12 with functional consequences.
medRxiv · Jan 17, 2026 · PreprintGenetic & Genomic Medicine