Polly J. Downton

The paper identifies 508 CKD-associated genetic loci, prioritizes 651 kidney genes, and highlights novel CKD genes like CA12 with functional consequences.

The paper corrects a TYR variant associated with albinism in patient-derived iPSCs to create a model for studying pigmentation biology.

This study shows that meal timing affects gut circadian rhythms, with interval feeding disrupting IEC clock transcripts and microbiota rhythms.

This study examines how colonic inflammation affects the intestinal circadian clock and immune function, finding altered clock function and new oscillations in regulatory T cells.

This study shows that fibroblast-like synoviocytes' circadian clock influences daily inflammation rhythms in arthritis, with Bmal1 deletion reducing arthritis susceptibility but increasing MMP3 production.