Author

Matthew J. Denniff

University of Leicester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:GWAS / association mapping· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Emma L WatsoniD· 2 shared Luke A. BakeriD· 2 shared Matthew P. M. Graham-BrowniD· 2 shared Nilesh J. SamaniiD· 2 shared Robert U. AshfordiD· 2 shared Abigail C. LayiD· 1 shared Adam S. ButterworthiD· 1 shared Alice Smith· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Emma L WatsonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Anabolic and catabolic responses to different modes of exercise in patients with chronic kidney disease

Doug William Gould, Luke A. Baker, Thomas J Wilkinson, Nicholas Eastly, Robert U. Ashford, Matthew J. Denniff, Matthew P. M. Graham-Brown, Alice Smith, João L. Viana, Andy Philp, Emma L Watson

This study examines how different exercise types affect skeletal muscle in CKD patients, finding that combined aerobic-resistance exercise improves anabolic signaling and myogenic responses compared to aerobic exercise alone.

BMC Nephrology · Mar 13, 2026Peer-reviewedMolecular Biology

Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteome

Amber Emmett, Xiaoguang Xu, Xiao Jiang, Shadi Hames-Fathi, David Scannali, James Eales, Ewa Miller‐Kasprzak, Polly J. Downton, Antony D. Adamson, Yong Sun, Abigail C. Lay, David Talavera, Matthew J. Denniff, John Dormer, Grzegorz Rempega, , Maciej Tomaszewski

The paper identifies 508 CKD-associated genetic loci, prioritizes 651 kidney genes, and highlights novel CKD genes like CA12 with functional consequences.

medRxiv · Jan 17, 2026 · PreprintGenetic & Genomic Medicine

Transcriptomic Suppression of Immune and Regenerative Signalling in Skeletal Muscle of Patients with Chronic Kidney Disease

Luke A. Baker, Nicholas C. Eastley, Robert U. Ashford, Matthew J. Denniff, Matthew P. M. Graham-Brown, Emma L Watson

This study identifies transcriptomic changes in CKD muscle, showing suppressed immune and regenerative pathways, with 76 differentially expressed genes.

bioRxiv · Jul 11, 2025 · PreprintMolecular Biology

A major population resource of 474,074 participants in UK Biobank to investigate determinants and biomedical consequences of leukocyte telomere length.

Veryan Codd, Matthew J. Denniff, Chloe Elizabeth Swinfield, Sophie Warner, Manolo Papakonstantinou, Shilpi Sheth, Dominika E. Nanus, Charley Ann Budgeon, Crispin Musicha, Vassiliki P. Bountziouka, Q. Wang, R. Bramley, Elias Allara, Stephen K. Kaptoge, Svetlana Stoma, , Nilesh J. Samani

The paper reports LTL measurements in 474,074 UK Biobank participants, identifying factors like age, sex, ethnicity, and white cell count associated with LTL variation.

Nature Aging · Feb 17, 2022Peer-reviewedGenetic & Genomic Medicine