Christoph Stein

This study sequenced 35,024 individuals with predominantly African ancestry to address gaps in genomics and healthcare, finding under-documented disease variants and novel associations with drug adverse events and glycemic control.

The paper identifies genetic risk factors for hypertriglyceridemia in African ancestry populations using whole genome sequencing and electronic health records.

This study investigates the clinical consequences of a genetic predisposition to lower white blood cell counts using a polygenic score and finds associations with bone marrow biopsy outcomes and treatment responses.

The paper develops a stochastic model of GPCR function in inflamed environments and validates it with experimental data, showing that low pH has a greater impact on GPCR behavior than radicals.