Systems BiologybioRxivPreprint
Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design
Sourav Ray, Arne Thies, Vikram Sunkara…·Stefanie Winkelmann
The paper develops a stochastic model of GPCR function in inflamed environments and validates it with experimental data, showing that low pH has a greater impact on GPCR behavior than radicals.