Functional microRNA targeting without seed pairing
Matthew H Hall, Peter Y. Wang, Thy Pham, David P. Bartel
The paper shows that microRNA targeting can occur without seed pairing, as 3'-only sites bind and repress mRNAs similarly to canonical sites, though with different kinetics and conformational effects.
Nucleic Acids Research · Oct 14, 2025Peer-reviewedMolecular Biology