Peter Y. Wang

The paper identifies VIPR systems, which use noncontiguous RNA codes for DNA recognition, suggesting an ancient origin of adaptive immunity through viral interactions.

This paper identifies how a human AGO-miRNA-trigger complex binds ZSWIM8 for CUL3-mediated polyubiquitylation, leading to target-directed miRNA degradation.

The paper shows that microRNA targeting can occur without seed pairing, as 3'-only sites bind and repress mRNAs similarly to canonical sites, though with different kinetics and conformational effects.

This paper presents the cryo-EM structure of a human AGO-guide complex bound to a fully paired target, revealing structural rearrangements that enable slicing-competent conformation and explain RNA slicing mechanism.

The paper introduces a statistical model to identify primary substrates of ZSWIM8-mediated microRNA degradation using small-RNA sequencing data, showing improved robustness and consistency compared to previous methods.