Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5
Mathilde Galais, Guillaume Herlem, Sandy Haidar Ahmad, Antoine Dutilleul, Sébastien Pasquereau, Ranim El Baba, Maxime Bellefroid, Estelle Plant, Stéphanie Morot-Bizot, Fabien Picaud, Georges Herbein, Carine M. Van Lint
The paper identifies two small molecules, Amb929 and Amb701, as potent inhibitors of SARS-CoV-2 nsp3 and nsp5, with Amb929 showing higher antiviral activity and lower cytotoxicity.
Biomedicine & Pharmacotherapy · Aug 4, 2026Peer-reviewedMicrobiology