Estelle Plant

The paper identifies two small molecules, Amb929 and Amb701, as potent inhibitors of SARS-CoV-2 nsp3 and nsp5, with Amb929 showing higher antiviral activity and lower cytotoxicity.

This study identifies KLF16 as a repressive transcription factor that inhibits HIV-1 transcription by competing with Sp1 and recruiting repressive complexes.

This study identifies lysine K686 as critical for BCL11b acetylation and nuclear localization, affecting its transcriptional activity and interactions with p300.

This study shows Dmrta2 represses Pax6 in cortical progenitors and identifies a DNA-binding mutation linked to microcephaly in humans.

This study shows CTCF regulates BLV transcription and 3D chromatin structure, affecting viral latency and host cell organization.