A Deep Learning-based Genome-wide Polygenic Risk Score for Common Diseases Identifies Individuals with Risk
Jiajie Peng, Jingyi Li, Ruijiang Han, Yuxian Wang, Lu Han, Jinghao Peng, Tao Wang, Jianye Hao, Xuequn Shang, Zhongyu Wei
This paper introduces DeepPRS, a deep learning-based polygenic risk score model that outperforms existing methods in predicting risk for common diseases using genome-wide genotype data.
medRxiv · Nov 17, 2021 · PreprintGenetic & Genomic Medicine