Jingyi Li

Unheralded high MHC Class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing

This study identifies highly polymorphic MHC class II genes in Atlantic herring using long-read sequencing, revealing exceptional diversity and coevolution of gene pairs.

Chicken shank color determined by Inhibition of dermal melanin (ID) is mediated by a structural variation regulating CDKN2A expression

This study identifies a structural variation in the CDKN2A gene that regulates shank color in chickens by inhibiting dermal melanin production.

Parallel evolution of LRP2 gene mediating telescope-eye and celestial-eye in goldfish

This study identifies a mutation in the LRP2 gene responsible for celestial-eye in goldfish and shows parallel evolution of this gene in different eye phenotypes under artificial selection.

Duck pan-genome reveals two transposon-derived structural variations caused bodyweight enlarging and white plumage phenotype formation during evolution

The paper constructs a duck pan-genome and identifies transposon-derived structural variations linked to bodyweight and white plumage traits in ducks.

A Deep Learning-based Genome-wide Polygenic Risk Score for Common Diseases Identifies Individuals with Risk

This paper introduces DeepPRS, a deep learning-based polygenic risk score model that outperforms existing methods in predicting risk for common diseases using genome-wide genotype data.

An exact transformation for CNN kernel enables accurate sequence motif identification and leads to a potentially full probabilistic interpretation of CNN

This paper introduces an exact transformation to convert CNN kernels to PWMs, enabling accurate motif identification and preserving CNN performance.