Author

William C. Thomas

Princeton UniversityORCID 0000-0001-5490-4900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1

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Audrey A. BurnimiD· 1 shared Da Zhuan XuiD· 1 shared Nozomi AndoiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

Audrey A. BurnimORCID

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1 paper

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BiophysicsNature CommunicationsPeer-reviewedMar 12, 2025

Conformational Landscapes of a Class I Ribonucleotide Reductase Complex during Turnover Reveal Intrinsic Dynamics and Asymmetry

Da Zhuan Xu, William C. Thomas, Audrey A. Burnim, Nozomi Ando

This study uses cryo-EM and deep learning to analyze conformational changes in ribonucleotide reductase during turnover, revealing dynamic asymmetry and transient states essential for catalysis.

9 citations

cryo-EMdeep learning

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