Ting‐Yi Wang

This study uses FRB-FKBP dimerization to disrupt Mlh1-Pms1 IDRs, revealing their role in DNA clamping during mismatch repair.

The paper shows that structure-based validation underestimates error rates in proteome-wide XL-MS and proposes four metrics for better quality assessment.

MaXLinker improves cross-link identification by reducing false positives and increasing sensitivity, revealing 9,319 cross-links in K562 cells.