BiophysicsCell ResearchPeer-reviewed
Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating
Ling Zhong, Xiaoqing Lin, Xinyu Cheng…·Panpan Hou
This study determines the structure of KCNQ1+KCNE1 in closed and open states, revealing structural transitions and dual PIP2 binding that regulate channel gating and IKs function.