NeurosciencebioRxivPreprint
(2R,6R)-Hydroxynorketamine elicits rapid antidepressant effects by promoting astrocytic μ-δ opioid receptor heterodimerization
Yanxia Liang, Lingjun Wang, Yajie Li…·Xiang Cai
This study identifies HNK's mechanism of action through astrocytic μ-δ opioid receptor heterodimerization, showing it restores these heterodimers and produces rapid antidepressant effects.
DOI 10.64898/2026.05.31.729044