Justin Eilertsen

The paper introduces a new framework for calculating drug-target occupancy time that incorporates association, dissociation, rebinding, and elimination rates, showing how these factors jointly influence in vivo efficacy.

The paper analyzes the validity of the total quasi-steady state approximation in the Michaelis-Menten reaction mechanism, showing its limitations at high initial substrate concentrations and identifying conditions under which it is a valid approximation.

The paper shows that ER stress sensors use a bidirectional mechanism to improve information about ER stress by integrating signals from unfolded proteins and chaperones.