BiochemistryAdvanced SciencePeer-reviewed
Replicating enzymatic activity by positioning active sites with synthetic protein scaffolds
Yujing Ding, Shanshan Zhang, Xian Kong…·Yifei Zhang
The paper demonstrates a computational strategy to design new PET hydrolases by replicating functional motifs from a template enzyme using deep learning and molecular computations, resulting in enzymes with high activity and thermostability.
17 citations