Peter D. Crompton

The paper shows memory Tregs reprogram into protective Tfh-like cells during recurrent malaria, enhancing antibody responses and parasite control.

The paper analyzes genetic diversity of the malaria parasite antigen MSP2 in Sub-Saharan Africa using PCR and long-read sequencing, revealing extensive sequence variation and regional prevalence patterns.

The paper compares var gene expression in asymptomatic Plasmodium falciparum infections and clinical malaria cases during dry and wet seasons in Mali, finding fewer and lower-level var transcripts in asymptomatic carriers.

The paper shows that malaria-experienced individuals have NK cells producing more IL-10, which may reduce inflammation and protect against malaria symptoms.

This study uses single-cell RNA-seq to profile seasonal changes in Plasmodium falciparum parasites, showing older parasites circulate in the dry season and transcriptional changes in exported proteins affecting cytoadhesion.

The paper develops DINEMITES, a statistical method to distinguish new from persistent infections using longitudinal genotyping data, showing improved accuracy over simple rules.