Author

Michael A. Sennett

ORCID 0000-0001-5660-4231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Activity by Year

2026-2026 · peak 1/yr

1 paper

Recent·Most cited

BiophysicsbioRxivPreprintJan 2, 2026

Sequence-Only Prediction of Antibody Fab Thermostability Using Protein Language Model Embeddings

Michael A. Sennett

This study predicts antibody Fab thermostability using sequence-only machine learning with IgBERT embeddings, achieving a PCC of 0.77 on internal data and 0.28 on clinical-stage therapeutics.

DOI 10.64898/2025.12.30.697053

humanprotein sequence

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