Minhui Chen

This paper introduces CTMM, a model to detect cell type-specific interindividual variation in scRNA-seq data, finding that most transcriptome-wide variability between donors is differentiation stage-specific.

The paper evaluates genotype imputation accuracy across global populations and finds disparities in performance for non-European ancestries, highlighting the need for more diverse reference panels.

This study identifies novel genetic loci for BMI, height, and WHRadjBMI in Hispanic/Latino populations and shows the benefits of ancestral diversity in GWAS.

This study identifies five novel genetic loci associated with childhood acute lymphoblastic leukemia through a trans-ethnic meta-analysis across four ethnic groups.

This study identifies 5,552 blood-cell trait-variant associations across 746,667 individuals from 5 global populations, including 71 novel loci and ancestry-specific variants not found in European ancestry populations.

The paper re-examines polygenic adaptation at height-associated loci in Sardinians and mainland Europeans using UKB and BBJ data, finding evidence of adaptation in Sardinians and a subtle signal in mainland Europeans.