Andréa R. V. R. Horimoto

A genomic-led strategy to anticipate drug safety effects

The paper uses Mendelian Randomization to predict adverse drug reactions by linking genetic variants to gene expression and protein abundance across large datasets.

Bridging the Genomic Equity Gap with Context-Enhanced Risk Stratification in American Indians: the Strong Heart Study

The paper improves risk prediction for cardiometabolic traits in American Indians by integrating polygenic scores with lifestyle and clinical context variables, enhancing model discrimination for coronary heart disease.

Leveraging Large-Scale Biobanks for Therapeutic Target Discovery

This study uses large biobanks to identify gene-trait pairs with causal evidence, rediscover approved drug targets, and develop a predictive model for drug development.

Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach with Pedigree Analysis and Family-Based Association Studies

This study identifies genetic loci and candidate genes associated with essential hypertension in African-Brazilian Quilombo populations using genome-wide linkage analysis and family-based association studies.

X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson Disease

The paper conducts an X-chromosome association study in Latin American cohorts, identifying new loci linked to Parkinson Disease and replicating previous findings.

Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort

The paper constructs and validates a polygenic risk score for Parkinson's disease in a Latino cohort, finding ancestry-related biases and haplotype associations at the SNCA locus.

Admixture mapping screening of CKD traits and risk factors in U.S. Hispanic/Latino individuals from Central America country-of-origin

The paper identifies ancestry-derived loci associated with CKD traits and risk factors in U.S. Hispanic/Latino individuals of Central American origin using admixture mapping.

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

This study identifies novel genetic loci for BMI, height, and WHRadjBMI in Hispanic/Latino populations and shows the benefits of ancestral diversity in GWAS.

Characterizing the genetic architecture of Parkinson's disease in Latinos

This study conducts the first GWAS of Parkinson's disease in Latinos, identifies SNCA as significant, and finds genetic overlap with Europeans.

Genome-wide admixture mapping of eGFR and CKD identify European and African ancestry-of-origin loci in U.S. Hispanics/Latinos

This study uses admixture mapping to identify ancestry-specific loci associated with eGFR and CKD in U.S. Hispanics/Latinos and validates findings in African Americans.

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

The paper identifies novel genetic loci associated with blood pressure that interact with sleep duration across multiple ancestries.

Genome-wide Analysis of Copy Number Variation in Latin American Parkinson's Disease Patients

The paper analyzes copy number variants in Latin American Parkinson's disease patients and finds enrichment of variants overlapping known Parkinson's genes, particularly PARK2, associated with early-onset disease.

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

The paper assesses if genetic risk for atrial fibrillation explains cardioembolic stroke risk using genome-wide data from the Stroke Genetics Network.