Yuhui Zheng

This study uses single-cell multi-omics to analyze transcript isoform and immune repertoire changes in aging human immune cells, identifying age-related molecular features in T cells and B cells.

This study identifies NAT10 as a regulator of TFH cell differentiation through the acC-TOX2 axis, showing that targeting NAT10 suppresses allergic asthma in mice.

This study uses single-cell multi-omics to analyze immune reconstitution failure in HIV patients, identifying genetic and epigenetic factors and developing a predictive model.

This study identifies molecular and cellular signatures of regular physical activity in human peripheral blood using multi-omics profiling, revealing enhanced metabolic and immune functions.

This study uses single-cell multi-omics data from the CIMA cohort to identify BMI-associated immune cell features and molecular mechanisms linked to immune-related diseases.

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

This study uses multi-omics data to analyze immune and metabolic changes in mountain climbers during acclimatization and extreme altitude exposure.

scPAFA efficiently computes pathway activity scores and identifies multicellular disease-related pathway modules in large-scale scRNA-seq data.