Yuxing Wang

Super-Resolution Visual ProteomEx for Hard Tissues and Clinical Samples

The paper introduces microProteomEx, a platform combining tissue expansion, imaging, and proteomics to achieve high-resolution spatial proteomics in hard tissues and clinical samples.

Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma

This study identifies THOC2 as a regulator of DNA repair and growth in HCC, showing that targeting THOC2 enhances PARPi efficacy by disrupting mRNA export of DDR genes.

Biosynthesis of bisbenzylisoquinoline alkaloids

This study identifies the enzymatic pathway for bisbenzylisoquinoline alkaloid biosynthesis and reveals a non-canonical redox-mediated mechanism for stereochemical control.

Decoding Immune Reconstitution Failure in People Living with HIV through Single-cell Genomics

This study uses single-cell multi-omics to analyze immune reconstitution failure in HIV patients, identifying genetic and epigenetic factors and developing a predictive model.

Multiscale transcriptomic organization of the human brain with DigitalBrain

DigitalBrain integrates and organizes human brain transcriptomic data across scales, revealing hierarchical organization and age-related gene reorganization.

Co-evolution of Oncogenic KRAS Signaling and LILRBhigh Macrophages Drives Pancreatic Cancer Recurrence

This study identifies a co-evolved tumor-immune interaction involving KRAS signaling and LILRBhigh macrophages that drives PDAC recurrence and presents a therapeutic strategy targeting this axis.

Mitochondria Organize Gap Junctions to Enable Neural Circuit Scaling

The paper shows mitochondria organize gap junctions during neural circuit growth by positioning mitochondria to recruit microtubule components, enabling coordinated neurite redistribution and electrical transmission.