Developmental BiologyNature CommunicationsPeer-reviewed
A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development.
Andrea Scarpa Wilderman, Eva D’haene, Machteld Baetens…·Justin L. Cotney
The paper identifies a critical noncoding superenhancer region essential for regulating anterior HOXA genes in craniofacial development, showing its deletion causes severe developmental defects in mice and a human patient.