Emma Wentworth Winchester

This paper presents a single-nucleus RNA sequencing atlas of human craniofacial development, revealing cell type contributions to facial variation and disease risk.

The paper identifies a critical noncoding superenhancer region essential for regulating anterior HOXA genes in craniofacial development, showing its deletion causes severe developmental defects in mice and a human patient.

The paper identifies novel disease candidate genes in craniofacial development using transcriptomics data and coexpression networks.

This study investigates the role of Dkk2 in palatogenesis using Pax9-/- mouse models and spatial multiomics data, revealing its spatial relationship with osteogenic populations.

The paper identifies candidate dental disease genes by integrating chromatin state, bulk gene coexpression, and single-cell RNA sequencing data from developing mouse teeth.

The paper identifies a gene signature specific to the enamel knot in developing mouse molars using scRNA-seq data and validates novel marker genes.