Author

Arkadi Hesin

Ariel UniversityORCID 0000-0001-5841-5469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anjana Edathil Kadangodan· 1 shared Julia A. YaglomiD· 1 shared Michael Y. ShermaniD· 1 shared Riham Barazi· 1 shared Vadim Levitt· 1 shared Valid GahramanoviD· 1 shared Yaakov MamaniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Anjana Edathil Kadangodan

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintAug 21, 2026

Systematic Generation of Mutations at Topoisomerase II Cleavage Sites Enables Cancer Adaptation to Doxorubicin Therapy

Valid Gahramanov, Anjana Edathil Kadangodan, Riham Barazi…·Michael Y. Sherman

The paper shows that cancer cells develop resistance to doxorubicin by accumulating mutations at Top2 cleavage sites, which prevent DNA damage and promote adaptation.

DOI 10.64898/2026.08.18.745411

humanexperimental assay

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