Tissue damage-induced axon injury-associated responses in sensory neurons: requirements, prevention, and potential role in persistent post-surgical pain
Kristofer K. Rau, Benjamin J. Harrison, Gayathri Venkat, Renée R. Donahue, Sara Petruska, Caitlin E. Hill, Bradley Kenneth Taylor, Jeffrey C. Petruska
This study investigates the role of ATF3 in pain following tissue damage, finding that axonal injury is necessary and sufficient for ATF3 induction, while inflammation and action potential conduction are not required.
Frontiers in Pain Research · Nov 14, 2025Peer-reviewedNeuroscience