Renée R. Donahue

AAV tools enable functional modulation and readout of central and peripheral nervous systems in spiny mice

The paper identifies AAV vectors that efficiently deliver transgenes to the nervous systems of spiny mice, enabling functional studies of regeneration.

Tissue damage-induced axon injury-associated responses in sensory neurons: requirements, prevention, and potential role in persistent post-surgical pain

This study investigates the role of ATF3 in pain following tissue damage, finding that axonal injury is necessary and sufficient for ATF3 induction, while inflammation and action potential conduction are not required.

Parkinsons disease modeling in regenerative spiny mice (Acomys dimidiatus) captures key disease-relevant behavioral, histological, and molecular signatures

This study models Parkinson's disease in spiny mice, showing they exhibit key disease features like behavioral impairments, neuronal degeneration, and proteomic changes similar to PD.

Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction

This study shows that spiny mice (Acomys) have better cardiac recovery after myocardial infarction compared to common lab mice, with less scarring and better function.