BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR Variant
Patrick J. Carmody, Francis J. Roushar, Austin Tedman…·Jonathan P. Schlebach
This paper identifies an RNA structure in the CFTR transcript that promotes ribosomal frameshifting and premature termination, enhancing the function and pharmacological rescue of the misfolded {Delta}F508 CFTR variant.
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