ImmunologybioRxivPreprint
Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer
Hemant Gujar, Sarah Hanache, Sadhna Aggarwal
The paper identifies age- and smoking-associated SPP1high tumor-associated macrophages in HPV-negative oral cancer that promote tumor progression by remodeling the extracellular matrix and suppressing antitumor immunity.