Khyobeni Mozhui

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

The paper tracks epigenetic biomarkers of health and aging in trans individuals during the first year of gender-affirming hormone therapy, finding treatment-specific changes in some biomarkers with notable individual variability.

This study investigates the long-term epigenetic effects of Gulf War illness by analyzing DNA methylation in mice exposed to stress and organophosphate compounds.

This study identifies Apbb1ip as a genetic modulator of immune gene co-expression in aged mouse hippocampus, revealing age-related transcriptomic changes and immune response upregulation.

The paper identifies a regulatory hotspot, meQTL.5a, that influences DNA methylation, gene expression, and aging traits in mice through genetic and age-related factors.

This study identifies genetic loci and metabolic factors associated with epigenetic aging in mice, showing links between DNA methylation entropy, diet, and life expectancy.

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

This study examines the relationship between body weight, epigenetic aging, and lifespan in BXD mouse strains, finding that higher body weight and high-fat diet accelerate epigenetic aging and shorten lifespan.

This study examines DNA methylation changes in the OPRM1 promoter in response to short-term opioid use, finding significant associations between opioid dosage and methylation levels.

The paper assesses DNA methylation in inbred mouse strains using the Illumina MethylationEPIC array, finding limited conserved CpGs but reliable results for differential methylation.