Soke Yuen Yong

The paper analyzes genetic variants used in disease risk predictors and finds that most SNPs are outside coding regions, suggesting exome data alone cannot capture heritability for complex traits.

This study constructs polygenic risk scores for multiple complex diseases using UK Biobank data and LASSO regression, achieving AUCs between 0.58 and 0.71, with improvements when incorporating age, sex, and larger case populations.