Laurent C. A. M. Tellier

The paper constructs a polygenic health index using disease risk scores and validates it in the UK Biobank, finding higher scores correlate with reduced disease risk and longer life expectancy.

This paper introduces a phenotype-specific framework to identify causative nonsynonymous variants in eye abnormalities, achieving high accuracy and precision in pathogenicity prediction.

This study constructs polygenic risk scores for multiple complex diseases using UK Biobank data and LASSO regression, achieving AUCs between 0.58 and 0.71, with improvements when incorporating age, sex, and larger case populations.

The paper constructs genomic predictors for human height, heel bone density, and educational attainment using machine learning, capturing significant variance and resolving part of the missing heritability problem.