This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

137 citationstop 1%

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsNature GeneticsPeer-reviewedJan 18, 2021

Large-scale association analyses identify host factors influencing human gut microbiome composition

Alexander Kurilshikov, Carolina Medina‐Gómez, Rodrigo Bacigalupe…·Oluf Borbye Pedersen

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

1,785 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicinePLoS MedicinePeer-reviewedJun 19, 2020

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

Naeimeh Atabaki‐Pasdar, Mattias Ohlsson, Ana Viñuela…·Paul W. Franks

This study develops machine learning models to predict liver fat content using multi-omic and clinical data from NAFLD patients, achieving higher accuracy than existing tools.

97 citationstop 1%

humanmetabolomics

𝕏 PostBluesky

GeneticsDiabetes CarePeer-reviewedMar 18, 2019

Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen…·A. Forman

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.

72 citationstop 2%

humanstatistical model

𝕏 PostBluesky