Leen M. ‘t Hart

The paper replicates ten novel loci associated with human plasma N-glycosylation using MALDI-MS and UHPLC-FD data and identifies potential causal genes.

The paper identifies cell type-specific lncRNAs in human kidneys and finds TARID, a podocyte-specific lncRNA, is upregulated in diabetic kidney disease and critical for actin cytoskeleton reorganization.

The paper identifies shared genetic regulation across mRNA, proteins, and metabolites in blood, revealing networks and mediators of GWAS variants.

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

This study develops machine learning models to predict liver fat content using multi-omic and clinical data from NAFLD patients, achieving higher accuracy than existing tools.

The paper introduces the R-package CONQUER to analyze type 2 diabetes risk loci by integrating genomic and epigenomic data, revealing tissue-shared effects on metabolic and HLA pathways.

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.