Author

Hartmut Ruetten

Sanofi (Germany)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:GWAS / association mapping· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Adem Y. DawediD· 4 shared Andrea MariiD· 4 shared Angus G. JonesiD· 4 shared Anubha MahajaniD· 4 shared Imre J. PavoiD· 4 shared Leen M. ‘t HartiD· 4 shared Mark HaidiD· 4 shared Mun‐Gwan HongiD· 4 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersGenetic & Genomic Medicine

Adem Y. DawedORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study.

Andrew Anand Brown, Juan J. Fernandez-Tajes, Mun‐Gwan Hong, Caroline Brorsson, Robert Wilhelm Koivula, David Davtian, Théo Dupuis, Ambra Sartori, Theodora-Dafni Michalettou, Ian M. Forgie, Jonathan Adam, Kristine Højgaard Allin, Robert J. Caiazzo, Henna Cederberg, Federico De Masi, , Ulrik Plesner Jacobsen

The paper identifies shared genetic regulation across mRNA, proteins, and metabolites in blood, revealing networks and mediators of GWAS variants.

Nature Communications · Aug 21, 2023Peer-reviewedGenetic & Genomic Medicine

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

Adem Y. Dawed, Andrea Mari, Andrew Anand Brown, Timothy James McDonald, Lin Li, Shuaicheng Wang, Mun‐Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Charles Langford Gough, Leen M. ‘t Hart, Kaixin Zhou, , A. Jonsson

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

The Lancet Diabetes & Endocrinology · Dec 15, 2022Peer-reviewedGenetic & Genomic Medicine

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

Naeimeh Atabaki‐Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares‐Millan, Mark Haid, Angus G. Jones, Elizabeth Louise Thomas, Robert Wilhelm Koivula, Azra Kurbasic, Pascal M. Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y. Dawed, Giuseppe Nicola Giordano, , Paul W. Franks

This study develops machine learning models to predict liver fat content using multi-omic and clinical data from NAFLD patients, achieving higher accuracy than existing tools.

PLoS Medicine · Jun 19, 2020Peer-reviewedGenetic & Genomic Medicine

Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert Wilhelm Koivula, Petra J. M. Elders, Simone P. Rauh, Angus G. Jones, Reinhard Walter Holl, Julia Stingl, Paul W. Franks, Mark I. McCarthy, Leen M. ‘t Hart, Ewan R. Pearson, , A. Forman

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.

Diabetes Care · Mar 18, 2019Peer-reviewedGenetics