Erkki Tapio Isometsä

This study identifies ultra-rare damaging variants in schizophrenia risk genes and shows they are associated with earlier hospitalizations, greater childhood adversity, and poorer neuropsychological outcomes across psychotic disorders.

The paper identifies five distinct depression phenotypes using MEG-oscillation functional connectivity and low-dimensional brain-symptom associations.

This study identifies eight genes associated with adult cognitive function through rare coding variants and shows how KDM5B dosage affects cognitive traits in mice and humans.

The paper investigates six rare SLCO1B1 variants in Finnish individuals with psychosis, finding one variant causes loss-of-function and reduced OATP1B1 protein expression.

The paper constructs a CYP2D6 copy-number imputation panel and reports pharmacogenetic variant frequencies in Finnish individuals with psychosis, showing high imputation accuracy but limited clinical utility.

The paper identifies rs165940 as a functional variant in the PDE4D gene associated with major mental illness in the Finnish population, particularly psychosis and cognitive domains.