Tiina Paunio

This study identifies ultra-rare damaging variants in schizophrenia risk genes and shows they are associated with earlier hospitalizations, greater childhood adversity, and poorer neuropsychological outcomes across psychotic disorders.

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

This study links gut transit time, inferred from stool consistency, to microbial metabolites and microbiota in infants, showing associations with breastfeeding, bile acid metabolism, and short-chain fatty acids.

This study examines how human milk metabolites relate to the infant gut microbiome and metabolome over time, finding time-dependent associations and differential influences based on dietary changes.

This paper identifies SORCS3 as a novel genetic locus associated with panic disorder through a genome-wide association study in the FinnGen study and validates it in independent samples.

This study identifies eight genes associated with adult cognitive function through rare coding variants and shows how KDM5B dosage affects cognitive traits in mice and humans.

This study shows that COMT and BDNF genetic variants affect neuronal oscillation synchronization and dynamics in humans.

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

The paper constructs a CYP2D6 copy-number imputation panel and reports pharmacogenetic variant frequencies in Finnish individuals with psychosis, showing high imputation accuracy but limited clinical utility.

The paper investigates how the BDNF Val66Met polymorphism influences auditory prediction plasticity in musicians versus non-musicians using MEG.

This study examines the effect of COMT Val158Met polymorphism on neural responses to deviant auditory stimuli using MEG in healthy participants.

This study identifies genetic variants associated with nightmares and finds strong genetic links between nightmares and psychiatric and sleep traits.

This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.

The paper identifies rs165940 as a functional variant in the PDE4D gene associated with major mental illness in the Finnish population, particularly psychosis and cognitive domains.

The paper investigates how genetic variation at the NDE1 locus affects gene expression and treatment response to psychiatric medications through interactions with microRNA-484 and CYP2C19.