Author

Diannan Lu

Tsinghua UniversityORCID 0000-0001-5993-5626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Guoqiang JiangiD· 1 shared Jianzhong WuiD· 1 shared Kaiyi ZhuiD· 1 shared Yilei HaniD· 1 shared Yupei JianiD· 1 shared Zheng LiuiD· 1 shared Zihao LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

Guoqiang JiangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJan 21, 2026

PocketGNN: A Cross-Modal Framework Unifying Local 3D Pocket Geometry and Global Sequence Semantics for Enzyme Kinetic Prediction

Zihao Li, Diannan Lu

PocketGNN predicts enzyme kcat by integrating local 3D pocket geometry and global sequence semantics, achieving high accuracy and robustness across splits.

DOI 10.64898/2026.01.19.700244

protein structuredeep learning

𝕏 PostBluesky

BiophysicsACS CatalysisPeer-reviewedSep 1, 2025

Substrate tunnel regulates substrate specificity switching in hyaluronan synthase

Kaiyi Zhu, Yupei Jian, Yilei Han…·Zheng Liu

This study identifies how the substrate tunnel in hyaluronan synthase regulates substrate specificity switching through dynamic interactions and allosteric regulation.

2 citations

experimental assay

𝕏 PostBluesky