Author

Chimene A. Kesserwan

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-6043-2065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-exome sequencing· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Sharon E. PloniD· 2 shared Aman PateliD· 1 shared Amanda B. SpurdleiD· 1 shared Arjen R. MensenkampiD· 1 shared Brian H. ShirtsiD· 1 shared Bryony A. ThompsoniD· 1 shared Carla OliveíraiD· 1 shared Carolina Pardo· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Sharon E. PlonORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintFeb 28, 2026

Distinct mutational landscapes when comparing germline and somatic cancer variants in forty tumor suppressor genes.

Suhasini D. Lulla, Deborah Ritter, Chimene A. Kesserwan, Sharon E. Plon

The paper compares germline and somatic variants in 40 tumor suppressor genes, finding distinct mutational patterns and locations shaped by different selection pressures.

DOI 10.64898/2026.02.26.707048

humanwhole-exome sequencing

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Genetic & Genomic MedicinemedRxivPreprintNov 1, 2021

ClinGen CDH1 specifications for the ACMG/AMP guidelines: improvement of germline variant clinical assertions and updated curation guidelines

Xi Luo, Jamie L. Maciaszek, Bryony A. Thompson…·Rachid Karam

The paper updates CDH1 variant curation guidelines to resolve conflicting interpretations and reduce variants of uncertain significance for clinical use.

DOI 10.1101/2021.11.01.21265332

humanstatistical model

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BioinformaticsGenome ResearchPeer-reviewedSep 1, 2019

Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): A Cloud-based Platform for Curating and Classifying Germline Variants

Michael N. Edmonson, Aman Patel, Dale J. Hedges…·Jinghui Zhang

PeCanPIE is a cloud-based platform for annotating and classifying germline variants in pediatric cancer, using ACMG guidelines to rank and classify variants from VCF files.

49 citations

humanwhole-exome sequencing

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